Research

Lab Summary

The overall goal of our laboratory is to understand the interplay between cerebral hemodynamics and critical clinical pediatric conditions and interventions. Our research is focused on the development, validation, and translation of various optical and MRI tools with the ultimate goal of clinical therapeutic implementation. Through multi-disciplinary collaborations Daniel Licht and his colleagues have utilized advanced MR techniques, and novel optical monitoring devices to probe the neurologic states that exist amongst survivors of complex conditions including rare congenitial cardiac conditions, ECMO, cardiac arrest, and stroke. 

Current Projects

Congenitial Heart Defects: MRI, Diffuse Optical Spectroscopy (DOS), and Diffuse Correlelation Spectroscopy (DCS) measures in a congential heart defect population at CHOP. To date we have enrolled over 180 subjects in this study. (Tiffany Ko is pictured to the right taking an optical measurement for this study)

Animal Study Models: DOS and DCS validation studies in animal populations undergoing both cardiopulmonary bypass and cardiac arrest. To date, we have conducted studies on over 100 animals. 

ECMO: To assess the cerebral hemodynamic states of patients on ECMO to better understand the effects that ECMO has on cerebral autoregulation. 

Pediatric Stroke: To assess the effects that hospital bed angle has on cerebral hemodynamics in a pediatric stroke patient cohort. 

Sleep Apnea: To assess cerebral blood flow and cerebral oxygenation in a pediatric sleep apnea patient cohort. 

Hydrocephalus: A non-invasive optical instrument validation study to assess intracranial pressure in a population of pediatric hydrocephalus.  

 

If you are interested in a potential collaboration please do not hesitate to reach out to Dan Licht.